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pirlygenes #452 (PR pirl-unc/pirlygenes#454) reclassifies MESENCHYMAL: it was CAF/stromal markers (TME signal in every solid tumor), so it has been removed from cancer_family_panels() (the tumor-lineage ...

Problem Statement Maintainers need a small, low-risk PRD Issue that can exercise PullOps GitHub Actions parent/child workflows without changing runtime behavior. Solution Create a Parent Issue with ...
ready-for-agent

Sub-task of #223 (D40 split). The first-roast gate (D40.1) — uses the #224 harness + dataset. Goal: de-risk the contexted+gated post-FC loop on OUR data before beans (operator chose this over shadow-mode): ...

Sub-task of #223 (D40 split). The loop wiring + the gate. Goal: from FC to drop, consult the LLM (~5 s cadence); the controller s outer loop decides execute-or-not. - Every recommendation passes the ...

Goal Set up a clean frontend structure before adding more pages and features. The goal is to prepare the frontend architecture now, so future issues can add features without repeatedly refactoring the ...

Sub-task of #223 (D40 split). Implements the D40.3 + D40.5 context. Goal: build the per-tick user context the post-FC loop sends: - the roast-so-far telemetry curve up to time t — bean / env / heat ...

Sub-task of #223 (D40 split). Implements D39.1 (§8.1). Named deliverable. Goal: a stable system message (distinct from the per-tick user context so it caches) that teaches the control model: the Hottop ...

Sub-task of #223 (D40 split). Implements D39.2 + D39.3 (plan.md §1 D39; deterministic-control-loop-plan.md §8.2/8.3). Goal: the per-phase RoastControlPolicy is the ONE place control limits are defined, ...

Problem When the album audio file is already fully available in the persistent range cache, RPlayer Gateway Viewer can serve playback ranges from cache immediately after startup. However, the visible ...
enhancement

!-- sentinel:error-fingerprint:43ce1999a27144ae -- Problem Sentinel captured a ci_failure error from ci-health. Observed Error 3 managed-app PR(s) have failing CI checks. Suspected Area ci Context ...
autonomy
codex
needs-approval
priority:high
reliability
self-heal:escalate
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Learn how you can use GitHub Issues to plan and track your work.

Save views for sprints, backlogs, teams, or releases. Rank, sort, and filter issues to suit the occasion. The possibilities are endless.Learn more about GitHub Issues
ProTip! Restrict your search to the title by using the in:title qualifier.