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Description
The current test suite for Quadratic-Solver covers:
- Distinct real roots
- Repeated real roots
- Complex roots
- Invalid coefficient (a = 0)
- Several interactive CLI flows
However, ...
type:bug
jyotish6699
Task
Implement _post_vep_batch() in src/clarvar/annotator.py.
Build a JSON payload and POST to the VEP endpoint:
{
variants : [ 1 100 100 A/T 1 , ...],
CADD : 1,
gnomAD : 1,
ClinVar ...
annotator
intermediate
NosakhareOsaro
Task
Implement _apply_vep_result() in src/clarvar/annotator.py.
This ties together the helper functions from issues #1–#4 and writes all annotation fields onto a Variant object
in-place.
From the most ...
annotator
intermediate
@ Analysis of shots.db (2026-06-09, n=269 shots on gp/trajectory_* predictors) to explain the low and inconsistent make
rate.
Findings
1. Aim is fine; mislaunches are the problem. Misses are bimodal: ...
minigame:hoops
jandersson
Task
Implement _pick_most_severe_transcript() in src/clarvar/annotator.py.
VEP returns a list of transcript_consequences, each with a consequence_terms list. Use the CONSEQUENCE_SEVERITY dict
(already ...
annotator
good first issue
Task
Implement _extract_clinvar() in src/clarvar/annotator.py.
ClinVar data lives in:
hit[ colocated_variants ][i][ clin_sig ] # list of strings
hit[ colocated_variants ][i][ ...
annotator
good first issue
Bug Description i got switched to opus 4.8 while working on a cybersecurity benchmark task for terminal bench 3
Environment Info
- Platform: darwin
- Terminal: cursor
- Version: 2.1.170
- Feedback ...
john7rho
Task
Implement _extract_gnomad_af() in src/clarvar/annotator.py.
gnomAD frequencies are nested inside the VEP response:
hit[ colocated_variants ][i][ frequencies ][allele][ gnomad ]
Also check for ...
annotator
good first issue
Goal
Convert the directional ~30% token savings (N=2 clean pairs) into a publishable measurement. This is simultaneously the
dev-tool proof point and the publication minimum — the single highest-leverage ...
evaluation
priority-high
track-b-paper
aryan5v
Task
Implement _to_vep_region() in src/clarvar/annotator.py.
The Ensembl VEP REST API requires variants to be submitted as a region string.
Format: {chrom} {pos} {end} {ref}/{alt} 1 where end = pos ...
annotator
good first issue
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Learn how you can use GitHub Issues to plan and track your work.
Save views for sprints, backlogs, teams, or releases. Rank, sort, and filter issues to suit the occasion. The possibilities are endless.Learn more about GitHub IssuesProTip! Restrict your search to the title by using the in:title qualifier.